PART III: THE STEM CELL CONCEPT Introducing Organogenesis

Where possible, references have been linked to PubMed, the National Center for Biotechnology Information’s online database of journal article citations. Citations that do not include links to PubMed are either referring to papers that are too old to be included in PubMed, or to books, which are not listed on PubMed.

Barker, N. and 10 others. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003–1007.
PubMed Link

Becker, A. J., E. A. McCulloch and J. E. Till. 1963. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197: 452–454.
PubMed Link

Bianchi, D. W., G. K. Zickwolf, G. J. Weil, S. Sylvester and M. A. DeMaria. 1996. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA 93: 705–708.
PubMed Link

Buchanan, A. E. 2011. Better Than Human: The Promise and Perils of Enhancing Ourselves. New York: Oxford University Press.

Caplan, A. I. 1991. Mesenchymal stem cells. J. Orthoped. Res. 9: 641–650.
PubMed Link

Carvey, P. M., Z. D. Ling, C. E. Sortwell, M. R. Pitzer, S. O. McGuire, A. Storch and T. J. Collier. 2001. A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: A source of cells for transplantation in Parkinson’s disease. Exp. Neurol. 171: 98–108.
PubMed Link

Cyranoski, D. 2013. Human stem cells created by cloning. Nature 497: 295–296.
PubMed Link

Dezawa, M. and 7 others. 2005. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309: 314–317.
PubMed Link

Dresser, R. 2010. Stem cell research as innovation: Expanding the ethical and policy conversation. J. Law Med. Ethics 38: 332–341.
PubMed Link

Engler, A. J., S. Sen, H. L. Sweeney and D. E. Discher. 2006. Matrix elasticity directs stem cell lineage specification. Cell 126: 677–689.
PubMed Link

Faden, R. R. and 19 others. 2003. Public stem cell banks: Considerations of justice in stem cell research and therapy. Hastings Center Rep. 33 (Nov.-Dec.): 13–27.
PubMed Link

Friedenstein, A. J., K. V. Petrakova, A. I. Kurolesova and G. P. Frolova. 1968. Heterotopic of bone marrow: Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6: 230–247.
PubMed Link

Gilbert, S. F., A. Tyler and E. Zackin. 2005. Bioethics and the New Embryology: Springboards for Debate. Sinauer Associates, Sunderland, MA.

Gnecchi, M. and 9 others. 2009. Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells 27: 971–979.
PubMed Link

Goessling, W. and 16 others. 2011. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell 8: 445–458.
PubMed Link

Gronthos, S., M. Mankani, J. Brahim, P. G. Robey and S. Shi. 2000. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl. Acad. Sci. USA 97: 13625–13630.
PubMed Link

Hall, M. A. and 8 others. 2003. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc. Natl. Acad. Sci. USA 100: 992–997.
PubMed Link

Hall, V. J., J. Y. Li and P. Brundin. 2007. Restorative cell therapy for Parkinson's disease: A quest for the perfect cell. Semin. Cell Dev. Biol. 18: 859–869.
PubMed Link

Hanna, J. and 9 others. 2007. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318: 1920–1923.
PubMed Link

Hayashi, K., H. Ohta, K. Kurimoto, S. Aramaki and M. Saitou M. 2011. Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell 146: 519–532.
PubMed Link

Hayashi, K., S. Ogushi, K. Kurimoto, S. Shimamoto, H. Ohta and M. Saitou. 2012. Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science 338: 971–975.
PubMed Link

Hirata, Y., M. Sata, N. Motomura, M. Takanashi, Y. Suematsu, M. Ono and S. Takamoto. 2004. Human umbilical cord blood cells improve cardiac function after myocardial infarction. Biochem. Biophys. Res. Comm. 327: 609–614.
PubMed Link

Hsu, Y. C. and E. Fuchs. 2012. A family business: stem cell progeny join the niche to regulate homeostasis. Nature Rev. Mol. Cell Biol. 13: 103–114.
PubMed Link

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PubMed Link

Jackson, W. M., L.  J. Nesti and R. S. Tuan. 2010. Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opin. Biol. Ther. 10: 505–517.
PubMed Link

Jones, D. L. and A. J. Wagers. 2008. No place like home: Anatomy and function of the stem cell niche. Nature Rev. Mol. Cell Biol. 9: 11–21.
PubMed Link

Jurásková, V. and L. Tkadlecek. 1965. Character of primary and secondary colonies of hematopoiesis in the spleen of irradiated mice. Nature 206: 951–952.
PubMed Link

Kandyba, E., Y.  Leung, Y. B. Chen, R. Widelitz, C. M. Chuong and K. Kobielak. 2013. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc. Natl. Acad. Sci. USA 110: 1351–1356.
PubMed Link

Kara, R. J. and 10 others. 2012. Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation. Circ. Res. 110: 82–93.
PubMed Link

Kerr, D. A. and 9 others. 2003. Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J. Neurosci. 23: 5131–5140.
PubMed Link

Khosrotehrani, K. and D. W. Bianchi. 2005. Multi-lineage potential of fetal cells in maternal tissue: A legacy in reverse. J. Cell Sci. 118: 1559–1563.
PubMed Link

Khosrotehrani, K., K. L. Johnson, D. H. Cha, R. N. Salomon and D. W. Bianchi. 2004. Transfer of fetal cells with multilineage potential to maternal tissue. JAMA 292: 75–80.
PubMed Link

Kiger, A. A., D. L. Jones, C. Schulz, M. B. Rogers and M. T. Fuller. 2001. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science 294: 2542–2545.
PubMed Link

Kolf, C. M., E. Cho and R. S. Tuan. 2007. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res. Ther. 9: 204.
PubMed Link

Konstantinov, I. E. 2000. In search of Alexander A. Maximov: The man behind the unitarian theory of hematopoieis. Perspect. Biol. Med. 43: 269–276.

Kuhn, N. Z. and R. S. Tuan. 2010. Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis. J. Cell. Physiol. 222: 268–277.
PubMed Link

Lévesque, J.-P., F. M. Helwani and I. G. Winkler. 2010 The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization. Leukemia 24: 1979–1992 .
PubMed Link

Lander, A. D. and 8 others. 2012. What does the concept of the stem cell niche really mean today? BMC Biol. 10: 19.
PubMed Link

Malhotra, S. and P. W. Kincade. 2009. Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell 4: 27–36.
PubMed Link

Marson, A. and 19 others. 2008. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134: 521–533.
PubMed Link

Moore, K. A. and I. R. Lemischka. 2006. Stem cells and their niches. Science 311: 1880–1885.
PubMed Link

Mou, H. and 10 others. 2012. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 10: 385–397.
PubMed Link

Nazarov, I. and 10 others. 2012. Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Stem Cells Transl. Med. 1: 359–372.
PubMed Link

Ng, F. and 10 others. 2008. PDGF, TGF-b, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): Transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood 112: 295–307.
PubMed Link

Nishikawa, S., R. A. Goldstein and C. R. Nierras. 2008. The promise of human induced pluripotent stem cells for research and therapy. Nature Rev. Mol. Cell Biol. 9: 725–729.
PubMed Link

Normile, D. 2012. Stem cells move into prime time. Science Now, June 18 2012.
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Osawa, M., K. Hamada, H. Hamada and H. Nakauchi. 1996. Long-term lympho-hematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273: 242–245.
PubMed Link

Park, I. H. and 8 others. 2008. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451: 141–146.
PubMed Link

Perry, B. C. and 8 others. 2008. Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Tissue Eng. Part C Methods 14: 149–156.
PubMed Link

Pittenger, M. F. and 9 others. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284: 143–147.
PubMed Link

Raaijmakers, M. H. 2012. Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis. Int. J. Hematol. 95: 17–25.
PubMed Link

Raaijmakers, M. H. and 15 others. 2010. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464: 852–857.
PubMed Link

Robinton, D. A. and G. Q. Daley. 2012. The promise of induced pluripotent stem cells in research and therapy. Nature 481: 295–305.
PubMed Link

Sato, T. and 10 others. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262–265.
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Sato, T. and 9 others. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415–418.
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Scaffidi, P. and T. Misteli. 2008. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nature Cell Biol. 10: 452–459.
PubMed Link

Schofield, R. 1978. The relationship between the spleen colony-forming cell and the heaemopoietic stem cell. Blood Cells 4: 7–25.
PubMed Link

Seaberg, R. M. and D. van der Kooy. 2003. Stem and progenitor cells: The premature desertion of rigorous definitions. Trends Neurosci. 26: 125–131.
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Shackleton, M. and 8 others. 2006. Generation of a functional mammary gland from a single stem cell. Nature 439: 84–88.
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Shamblott, M. J. and 8 others. 1998. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc. Natl. Acad. Sci. USA 95: 13726–13731.
PubMed Link

Shevde, N., 2012. Stem cells: Flexible friends. Nature 483: S22–S26.
PubMed Link

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Simons, B. D. and H. Clevers. 2011. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145: 851–862.
PubMed Link

Snippert, H. J. 2010. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143: 134–144.
PubMed Link

Spiegel, A., A. Kalinkovich, S. Shivtiel, O. Kollet and T. Lapidot. 2008. Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell 3: 484–492.
PubMed Link

Stadtfeld, M. and 11 others. 2012. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nature Genet. 44: 398–405.
PubMed Link

Takagi , Y. and J. Takahashi. 2005. Primate embryonic stem cells as a source of dopaminergic neurons: A novel transplantation for Parkinson's disease. Disc. Med. 5: 219–223.
PubMed Link

Takahashi, K. and 6 others. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861–872.
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Takeda, N., R. Jain, M. R. LeBoeuf, Q. Wang, M. M. Lu and J. A. Epstein. 2011. Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420–1424.
PubMed Link

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PubMed Link

Thomson, J. A. and 6 others. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282: 1145–1147.
PubMed Link

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PubMed Link

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PubMed Link

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PubMed Link

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PubMed Link

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PubMed Link

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PubMed Link

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PubMed Link

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Citation for the BioWeb Conference Links
Barresi, M. J., and Lee, K. 2005–2010. Biology Web Conferences. Smith College, Northampton, MA.

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